On his first visit to Paris in 1902, Natalia Sedova found Trotksy a place to live at No 46. near her flat in Rue Lalande. The 14th arrondissement was a frequent choice of destination for the Russian social democrats of the late 19th century and early 20th century. One source suggests Trotksy was living there when he married Natalia in 1903.
The street was constructed in 1887 and given the name of the Pierre Gassendi (1592-1655), a mathematician, astronomer and philosopher.
In 1999 a public library was opened at No. 36 and named after the anarchist, poet and singer, Georges-Brassens.